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When you inadvertently "underdose" yourself by taking antibiotics that aren't full strength, he says, you run the risk that the bacteria you're battling will figure out not only how to defeat this weakened drug, but other antibiotics, too. "If your medicine has expired, don't use it," concurs Ilisa Bernstein, deputy director of the office of compliance in the Food and Drug Administration's Center for Drug Evaluation and Research.